Eric McCormack and Rachael Leigh Cook return as Dr. Daniel Pierce, the professor with paranoid schizophrenia and FBI agent Kate Moretti who is willing to look past his peculiarities.
In series two, Dr. Pierce’s personal life is even more complicated than usual. He finds it difficult to walk away from his imaginary friendship with Natalie Vincent, but he must do so in order to embark on a romance with his doctor, Caroline Newsome – both played by Kelly Rowan (The O.C.).
Special guest star Scott Wolf joins the cast as Donnie, Kate's soon-to-be ex-husband. A charismatic, fast-rising Assistant U.S. Attorney who recently transferred back to Chicago, Donnie seems less concerned with doing what’s right than with doing what’s right for Donnie. While he claims his transfer back to Chicago was completely random, it's clear he has a hidden agenda involving Kate.