Series thirteen continues to explore the personal and professional developments in the lives of Detective William Murdoch (Yannick Bisson), Dr. Julia Ogden (Helene Joy), Inspector Thomas Brackenreid (Thomas Craig), Constables George Crabtree (Jonny Harris) and Henry Higgins-Newsome (Lachlan Murdoch), and Detective Llewelyn Watts (Daniel Maslany) as they tackle Toronto's toughest mysteries, from the serious and historic to the comical and unusual.
Murdoch continues his deft detective work and bolsters his investigations with new innovations including a "searchizer" device that measures facial features and matches them with existing police files. Unfortunately, he is still rattled by suspicions about Violet Hart's (Shanice Banton) appointment to coroner and doesn't completely trust her abilities or motives. The station also sees a new addition with Special Constable Robert Parker (Marc Senior), an African American former Pinkerton who went from suspect in a union murder to helping solve the case.
Meanwhile, Ogden is happily settled into her role as a full-time surgeon at Toronto Mercy Hospital but is surprised by the attentions of her colleague Dr. Andrew Dixon (Sebastian Pigott).
Crabtree's creative streak continues with his new paramour, lawyer Effie Newsome (Clare McConnell), encouraging him to send his manuscript to publishers. And the stories of his past begin to unspool as his family reappears in his life. Sadly, Higgins-Newsome is feeling very discouraged by his inability to support his new wife Ruth (Siobhan Murphy) in the lifestyle she'd grown accustomed to and makes a hasty decision to stabilise his finances. Marriage tension is also on the mind of Brackenreid after admitting last year to Margaret (Arwen Humphreys) to a long-ago infidelity.