Set in Toronto, Canada in the late 19th century, Murdoch Mysteries is based on the best-selling novels by crime writer Maureen Jennings and follows the adventures of Detective William Murdoch (Yannick Bisson) who uses innovative inventions and pioneering forensic techniques to crack cases.
Murdoch is aided by the eager but inexperienced Constable George Crabtree (Jonny Harris), sceptical but supportive boss Inspector Brackenreid (Thomas Craig) and accomplished pathologist Dr Julia Ogden (Hélène Joy), Murdoch's staunch supporter and soulmate.
This series also introduces Dr Emily Grace (Georgina Reilly), Dr Ogden's feisty protégé, who is brought in to help out at the City Morgue and quickly learns the rules of the station house. George Crabtree seems especially taken with her... but will she share his romantic feelings?
At the end of Series 4, Julia Ogden had married Dr Darcy Garland and, heartbroken, Murdoch had turned in his police badge. Now in self-imposed exile in the harsh and hostile Yukon region of Canada, Murdoch joins the Klondike Gold Rush and gets caught up in a murder mystery that makes him realise his days as a detective are not yet behind him.
Later on, an old adversary returns to seek revenge and taunts Murdoch with talking dolls left at crime scenes, Murdoch investigates a professor whose claims of inventing a time machine are making him a lot of money and comes across the curious case of a mummy's curse being blamed for the death of some ancient Egypt archeologists.
Real-life historical figures that Murdoch encounters along the way this series include inventor Alexander Graham Bell, political activist Emma Goldman and 'The Call of the Wild' writer Jack London.