Based on the best-selling books by Meg Cabot, 1-800-Missing tells the story of Jess Mastriani (Caterina Scorsone), a woman whose life turns upside down when she's struck by lightning. After her accident she finds that she's gained psychic gifts, which manifest themselves as visions that help to find missing people. Employed by a special FBI task force, she's teamed with sceptical partner Brooke Haslett (Gloria Reuben).